| Grab Sources And More Here: Company Website. Company Presentation. -----
As mentioned above, (NYSE American: MAIA) has several explosive potential catalysts to consider right now. Check these out:
#1. MAIA Potential Catalyst - One Analyst's Target Suggests Over 950% Potential Upside From MAIA's Current Chart Levels.
Earlier this month, Robert LeBoyer, Senior Vice President and equity research analyst with Noble Life Science Partners, reiterated a $14.00 target on MAIA.
From Tuesday's closing valuation, that provides MAIA with upside potential over 950%!
Check out some key report highlights:
Conclusion. The start of Phase 3 is an important milestone toward FDA approval. If the study replicates the recent data from the Phase 2 trial, ateganosine could become significant new therapy for third-line NSCLC. We believe this would also provide significant proof-of-concept to support earlier use. We are reiterating our Outperform rating and $14 price target. -----
#2. MAIA Potential Catalyst - Volatility Potential Could Be Significantly Heightened Based On MAIA's Low Float.
According to info from the Yahoo Finance website, MAIA has a relatively low float.
The website reports this profile to have roughly 31.98Mn shares in its float.
Why is that important? It's important on one crucial level. Volatility potential.
If more positive company news pops up towards the end of 2025, could it provide a breakout spark when paired with this volatility potential? -----
#3. MAIA Potential Catalyst - Another Analyst Target Suggests Over 650% Potential Upside From Tuesday's Close.
Last month, an analyst at Diamond Equity Research provided an update note on their (NYSE: MAIA) coverage.
In the update, they retagged MAIA with a target of $10.27.
From Tuesday's close, that target provides MAIA with a potential upside of over 650%.
Here's some highlights from the report:
Valuation:
... With continued positive readouts, the initiation of THIO-104 (Phase 3 study) remains a key potential valuation catalyst, marking progression towards controlled clinical validation and potential registration. We have revised our valuation model to reflect the recent Q3 financial results, updated share count, and reassessed comparable company analysis, reiterating our valuation of $10.27 per share contingent on successful execution by the company. -----
#4. MAIA Potential Catalyst - A Major Milestone Is Achieved With First Patient Dosing In THIO-104 Phase 3 Trial.
MAIA Biotechnology Announces First Patient Dosed in THIO-104 Phase 3 Pivotal Trial Evaluating Ateganosine as Third-Line Treatment for Advanced Non-Small Cell Lung Cancer
Key milestone achieved as Company advances clinical program to full approval trial of ateganosine sequenced with a checkpoint inhibitor in comparison to chemotherapy
CHICAGO, Dec. 11, 2025 (GLOBE NEWSWIRE) -- MAIA Biotechnology, Inc. (NYSE American: MAIA) (“MAIA”, the “Company”), a clinical-stage biopharmaceutical company focused on developing targeted immunotherapies for cancer, today announced that the first patient has been dosed in the Company’s THIO-104 Phase 3 pivotal trial evaluating the efficacy of ateganosine administered in sequence with a checkpoint inhibitor (CPI) as a third-line treatment for advanced non-small cell lung cancer (NSCLC).
The multicenter, open-label trial of patients who are resistant to CPI and chemotherapy treatments, is designed to assess overall survival for ateganosine sequenced with a CPI compared to investigator’s choice of chemotherapy in a 1:1 randomization of up to 300 patients. MAIA has received regulatory approval to screen patients in Taiwan, Turkey, select European Medicines Agency (EMA) countries, and Georgia. Screening and enrollment are now underway.
“Our strategy to bring our telomere-targeting treatment to market is proceeding according to plan as we advance our ateganosine program to a Phase 3 trial. This larger trial will provide us a robust dataset to support our case for commercial approval by the U.S. FDA,” said Vlad Vitoc, M.D., CEO of MAIA. “We have many sites in several countries already screening patients, and with our first patient dosed, we have achieved a key milestone along our path to potential FDA commercial approval. We expect to see Phase 3 results consistent with Phase 2 trial data showing median survival of 17.8 months compared to approximately six months of survival from chemotherapy. We are confident that ateganosine could become the new treatment standard for patients suffering from this devastating disease.”
...
Read the full article here. -----
#5. MAIA Potential Catalyst - Insider Purchases Could Strike A Chord Of Significant Confidence In The Company's Future.
MAIA Biotechnology Announces Open Market Purchases by CEO and Directors
CHICAGO, Dec. 01, 2025 (GLOBE NEWSWIRE) -- MAIA Biotechnology, Inc. (NYSE American: MAIA) (“MAIA”, the “Company”), a clinical-stage biopharmaceutical company focused on developing targeted immunotherapies for cancer, today announced that the CEO and certain members of the Company’s Board of Directors purchased approximately 182,445 shares of MAIA common st-ock at market price between November 21 and 28, 2025. The average common stock price was $1.06.
Vlad Vitoc, M.D., Chairman and CEO of MAIA, purchased 94,300 shares between November 21 and 28, 2025, at an average price of $1.08 per share. Other board members, Cristian Luput and Stan V. Smith, Ph.D., purchased a combined total of 88,145 shares in the open market at an average price of $1.04 per share.
“Along with my fellow MAIA Board members, we are pleased to report that we recently acquired shares of MAIA in the open market, reflecting our confidence in ateganosine’s ongoing clinical development,” said Dr. Vitoc. “With 38% response rates and 17.8 months overall survival in our Phase 2 THIO-101 clinical trial to date, we believe in ateganosine’s potential to improve the lives of patients diagnosed with non-small cell lung cancer and become a new standard of care.”
...
Read the full article here. -----
MAIA Recap - This NYSE American Breakout Idea Has 5 Explosive Potential Catalysts
#1. One Analyst's Target Suggests Over 950% Potential Upside From MAIA's Current Chart Levels.
#2. Volatility Potential Could Be Significantly Heightened Based On MAIA's Low Float.
#3. Another Analyst Target Suggests Over 650% Potential Upside From Tuesday's Close.
#4. A Major Milestone Is Achieved With First Patient Dosing In THIO-104 Phase 3 Trial.
#5. Insider Purchases Could Strike A Chord Of Significant Confidence In The Company's Future. -----
We're kicking-off coverage on MAIA Biotechnology, Inc. (NYSE American: MAIA).
As soon as updates are available, we'll get them out to you quickly. Stay tuned.
Sincerely, FierceAnalyst | Jaks Swift Editorial Writer
(Always Remember The St-ock Prices Could Be Significantly Lower Now From The Dates I Provided.)
*FierceInvestor (FierceInvestor . com) is owned by SWN Media LLC, a limited liability company. Data is provided from third-party sources and FierceInvestor ("FI") is not responsible for its accuracy. Make sure to always do your own research and due diligence on any day and swing profile I bring to your attention. We do not provide personalized fin-ancial advice, are not finan-cial advisors, and our opinions are not suitable for all in-vest-ors.
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