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After Yesterday's MedTech Profile Made An Approx. 130% Move In Just A Few Hours, Krypton Street Puts (NCEL) Back On Today's Watchlist
Full Coverage Starts This Morning—Thursday, January 29, 2026.
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Consider Starting Your Own Research On (NCEL) While It's Still Early [Company Website] | [Corporate Presentation]
January 29, 2026
Clock's Ticking | See Why (NCEL) Has Our Full Focus Ahead of the Bell Dear Reader, Coming off of yesterday's Medtech profile that made an over 130% move (approx.) in just a few hours, we're now turning our attention to a biotech that we recently highlighted. 
The most powerful biotech moves often start quietly—before the wider market even notices. Today, that moment belongs to NewCelX Ltd. (Nasdaq: NCEL)—a Nasdaq-listed biotech stepping onto the global stage. And the timing is no coincidence. The last time we highlighted (NCEL) earlier this month, shares were just beginning to find their footing. From around $2.13 on January 5, shares of (NCEL) reached $2.83 —marking an approximate 32% move this month as the market begins to take notice. Now, (NCEL) is back at the top of our watchlist, starting this morning—Thursday, January 29, 2026.
But keep in mind, (NCEL) has less than 2.1M shares listed in its public float. When floats are this small, there's the potential for big moves if demand begins to shift. Right now, (NCEL) is hovering in the $2 - $3 range, appearing to fly under the radar of my screens—even as the story behind it accelerates. After months of coordination, regulatory clearance, and shareholder approval, (NCEL) has officially been listed on the Nasdaq Capital Market—marking the beginning of a company built to push the boundaries of regenerative medicine and neuroscience
And the timing couldn't be more significant.
Keep reading to see why (NCEL) just landed back on our radar. A Major Scientific Milestone
NewcelX (NCEL) recently reported positive results from a peer-reviewed international study focused on a key challenge in Type 1 diabetes cell therapy: how to deliver stem-cell-derived islets in a way that supports function without ongoing immune suppression. Published in Diabetology and conducted with multiple research institutions—including the University of Technology Sydney and the University of Wisconsin-Madison—the study tested engineered scaffolds that incorporate extracellular matrix (ECM) from a decellularized human pancreas inside a removable delivery system. The results showed that adding ECM to the scaffold helped implanted islets perform comparably to encapsulated islets delivered without a scaffold. This supports the breakthrough idea that biomaterials and the tissue microenvironment can materially influence islet function and may enable safer, retrievable delivery designs for future development. The work was backed by AFDR-led funding and received additional support from Breakthrough T1D (formerly JDRF) to further develop the model. Management positioned the findings as aligned with the scientific foundation of its IsletRx program and as a step that helps inform continued development as the company moves toward clinical trial planning. This breakthrough landed just after (NCEL) announced the appointment of Dr. Julien Boisdron, MD to its Scientific Advisory Board—an announcement that immediately stood out to me because of who he is. Dr. Boisdron is currently Global Head of OneMedical and Chief Medical Officer for Roche Diabetes Care, operating under Roche Holding AG (~$450B market cap)—a global healthcare powerhouse. That kind of leadership doesn't attach itself to early-stage programs unless something meaningful is forming behind the scenes. The markets that (NCEL) is stepping into—neurodegenerative disease, metabolic disorders, and central nervous system conditions—collectively represent well over $300B in combined annual potential over the next decade.
And the metabolic side of that story is accelerating fast: the Metabolic Disorders Therapeutics Market was valued at $74.97B in 2024 and is forecast to nearly double to $157.65B by 2033—a powerful tailwind for programs targeting insulin-dependent diabetes. Within that, regenerative medicine alone is valued at over $43B in 2025 and projected to surpass $212B by 2034—fueling the next wave of global medical innovation. That's the arena NewCelX Ltd. (Nasdaq: NCEL) is aiming to compete in. But this isn't just a new name. It's the start of a new era for a biotech that now stands at the intersection of cell therapy, neuroscience, and global science leadership—linking Swiss precision, Israeli innovation, and U.S. visibility under one roof. Milestones Now in Motion
What makes this setup even more exciting for us, is that (NCEL) is now issuing the kind of updates that signal the story is no longer theoretical—it's active. In a recent letter to shareholders, CEO Ronen Twito outlined a defined 12-month roadmap across the company's three core platforms—IsletRx (diabetes), AstroRx® (ALS), and DOXA (CNS/metabolic science)—laying out near-term milestones that point to accelerating execution. At the same time, (NCEL) has strengthened scientific credibility by adding two major names to its Scientific Advisory Board—Prof. Tamir Ben-Hur (Hadassah Medical Center) and Dr. Jeremy Shefner (Barrow Neurological Institute)—deepening its bench in neurodegenerative medicine. And in another important move, (NCEL) expanded its intellectual property reach by publishing a DOXA patent application in China, extending long-term protection for its neuroscience platform onto one of the world's most important stages. And those developments are landing at a moment when the markets NewCelX is targeting are accelerating at massive scale. Massive Markets, Accelerating Fast
The markets surrounding (NCEL) are expanding fast—and the numbers explain why. What makes the metabolic story stand out is that (NCEL)'s diabetes program isn't theoretical—it has already reached a key U.S. regulatory checkpoint with a successful Type B pre-IND meeting with the FDA. Meanwhile, CNS therapeutics are projected to expand from roughly $127B in 2025 to more than $267B by 2034, aligning with (NCEL)'s DOXA platform and broader neuroscience strategy. And with regenerative medicine projected to surge from over $43B in 2025 to more than $212B by 2034, (NCEL) is positioned directly in the path of one of biotech's most powerful innovation cycles. Inside The Engine Behind (NCEL)
What truly sets NewCelX apart is not just its global footprint or leadership team—it's the science at the core. At the heart of the company is a regenerative medicine platform built to produce "off-the-shelf" cell therapies designed to replace, restore, or repair malfunctioning cells with healthy, functional ones. Using proprietary stem-cell differentiation technology, (NCEL) can generate specialized human cells—including: - Insulin-secreting islet cells designed to regulate blood sugar
- Astrocytes, key support cells that help protect neurons
- And a parallel small-molecule platform designed to address CNS dysfunction through multi-target biology
Together, these form the foundation for three core programs: IsletRx / iTOL-102 (Diabetes), AstroRx® (ALS), and DOXA (CNS + metabolic platform science). IsletRx / iTOL-102: A Credible Push Toward Functional Restoration
in Type 1 Diabetes
Diabetes remains one of the largest and fastest-growing healthcare burdens in the world — and (NCEL) believes the next leap forward won't come from better management tools, but from restoring what insulin-dependent diabetes destroys: functional insulin-producing cells.
That's the goal behind IsletRx, (NCEL)'s stem-cell-derived therapy designed to deliver a scalable, purified supply of insulin-secreting pancreatic islet cells — built to sense glucose and release insulin naturally. And importantly, this program has already reached an early U.S. regulatory checkpoint: (NCEL), along with its partners, successfully completed a Type B pre-IND meeting with the FDA for iTOL-102. This combination therapy pairs IsletRx cells with iTolerance's immune-modulating microgel iTOL-100, designed to reduce or potentially eliminate the need for chronic immunosuppression. And the credibility doesn't stop at regulatory dialogue. iTOL-102 was evaluated at the Diabetes Research Institute (DRI) at the University of Miami, where it was designated as a potential breakthrough transplantation approach. Reported results included functional insulin release and disease reversal in an animal model, alongside confirmed compatibility between IsletRx cells and iTOL-100. Based on FDA feedback, the program is now progressing toward a safety toxicology study. From there, the focus shifts to preparing for a first-in-human clinical trial. That puts this diabetes platform on an active path toward U.S. clinical development. In short: this isn't just a concept. It's a structured program moving forward with regulatory dialogue, institutional evaluation, and a defined path toward clinical entry. AstroRx®: One Arm Of The Platform
(NCEL)'s AstroRx® targets ALS through a regenerative approach—using lab-grown astrocytes designed to support and protect damaged neurons. Following a Phase 1/2a study in Israel showing safety and clinically meaningful signals, the FDA cleared a U.S. Phase 2a trial—placing (NCEL) among a small group advancing cell-based neurotherapies into U.S. clinical development. DOXA: The Discovery Engine Inside (NCEL)
The DOXA platform is designed to address complex CNS and metabolic disorders by targeting key pathways tied to sleep-wake regulation, inflammation, and metabolic function. Its dual-action approach—activating orexin receptors while inhibiting cathepsins—reflects (NCEL)'s strategy of combining regenerative medicine with next-generation neuroscience. And with a patent application now published in China, the company is laying groundwork for long-term protection and global reach as the platform evolves. 7 Reasons Why (NCEL) Is Topping This Morning's Watchlist
—Thursday, January 29, 2026
1. Low Float: With fewer than 2.1M shares available to the public, (NCEL)'s small float could see the potential for big moves if demand begins to shift. 2. Recent Momentum: After being highlighted near $2.13 earlier this month, (NCEL) reached roughly $2.83, reflecting an approximate 32% move. 3. Published Breakthrough: A newly published Diabetology study supports the scientific foundation behind (NCEL)'s diabetes platform through independently reviewed research results. 4. Regulatory Progress: Following a successful Type B pre-IND meeting with the FDA, (NCEL) has already crossed an early U.S. development checkpoint for its diabetes program. 5. Elite Advisors: With Roche Diabetes Care Chief Medical Officer Dr. Julien Boisdron joining its Scientific Advisory Board, (NCEL) has attracted leadership rarely seen at this stage. 6. Massive Markets: Operating across metabolic, neurodegenerative, and CNS conditions, (NCEL) is positioned within healthcare segments projected to exceed $300B combined over the next decade. 7. Active Roadmap: A recent shareholder letter outlined defined 12-month milestones across IsletRx, AstroRx®, and DOXA, signaling that execution for (NCEL) is already underway. Consider Starting Your Own Research On (NCEL) While It's Still Early [Company Website] | [Corporate Presentation]
What makes this setup especially compelling is how many powerful signals are converging at once. With less than 2.1M shares available to the public, (NCEL)'s small float could have the potential for big moves if demand begins to shift. At the same time, it's still hovering around the $2 - $3 range—quiet enough to slip beneath most screens, yet active enough that the story behind it is clearly accelerating. And this isn't happening in isolation. (NCEL) sits at the intersection of markets projected to exceed $300B in combined annual potential over the next decade, while a recent shareholder letter laid out a clear 12-month roadmap across IsletRx / iTOL-102, DOXA, and AstroRx®. What stands out most is the diabetes platform — already reaching an early U.S. regulatory checkpoint through a successful Type B pre-IND meeting with the FDA, and evaluated at the Diabetes Research Institute (DRI) at the University of Miami. Add in the strengthening of its scientific bench and the DOXA patent application published in China, and you start to see a company building depth, credibility, and long-term platform value. We have all eyes on (NCEL) this morning—Thursday, January 29, 2026. Consider starting your own research on (NCEL) while it's still early. Also, keep a lookout for my next update, it could be out to you very shortly. Sincerely,
Alex Ramsay
Co-Founder / Managing Editor Krypton Street Newsletter
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