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Jeff Ackerman Initiates Coverage On Tiziana Life Sciences (Nasdaq: TLSA) Starting This Morning—Wednesday, July 30, 2025
And Here's Why We Have All Eyes On (TLSA) Right Now…
(TLSA) Went From $0.63 To $1.98 Inside Of Just Six Months, A Move Of Approximately 214%.
Lucid Capital Recently Initiated Coverage On (TLSA) With A Target Of $8, Which Suggests Over 300% Upside Potential.
(TLSA) Is Now Trending Above Its 5-, 20-, 50-, 100-, And 200-Day Moving Averages.
The Executive Chairman Increased His Stake To Over 43Mn Shares, Exceeding 37% Ownership.
Pull Up (TLSA) This Morning—While It's Still Early…
July 30, 2025 Early Coverage | See Why (TLSA) Just Hit Our Morning Watchlist Dear Reader, Every once in a while, we come across a setup that doesn't just look different—it feels different. One where the data, the delivery, and the timing all start lining up. Right now, there's a name pushing into territory few others in biotech have dared to explore—and it's beginning to attract the kind of attention that doesn't stay quiet for long. In a world where many companies are simply tweaking what's already been done, Tiziana Life Sciences (Nasdaq: TLSA) is taking a radically different approach—reimagining how immunotherapy is delivered to the brain and central nervous system. And based on recent clinical progress, early data, and analyst coverage, it's clear: something significant is developing here.
This is not about hype. This is about science that's actually showing signs of doing what others haven't. In the last 6 months, (TLSA) has moved approximately 214% from 0.6302 on February 6, to $1..98 yesterday, July 29. Now, (TLSA) is trending above all major moving averages tracked by Barchart, including its 5, 20, 50, 100, and 200-Day metrics. Analyst Coverage Raises the Bar
Last week, Lucid Capital Markets initiated coverage on (TLSA), with a "Bullish" rating and a $8 target—which suggests over 300% upside potential from its recent levels. 
Their reasoning? - Foralumab's mechanism may be disease-modifying, not just symptom-managing
- No current FDA-approved therapy targets non-active SPMS, a high-burden segment of the MS community
- Lucid projects U.S. net sales potential of $1.6B and EU5 sales of $1B, assuming 50% market share by 2030
- The commercial window for nasal foralumab could extend through 2043
Lucid draws a bold comparison: positioning (TLSA)'s foralumab as a potential "Humira for CNS disorders." That's not casual language—Humira became the world's best-selling therapy for years, generating over $20B annually at its peak. The Core Technology: Nasal Foralumab, the First of Its Kind
At the heart of (TLSA)'s program is foralumab, a fully human anti-CD3 monoclonal antibody. But this isn't your typical mAb. Instead of the standard IV infusion that comes with systemic immune risks and long clinic visits, (TLSA) is pioneering a nasal delivery system. It's non-invasive. It bypasses the bloodstream. And it targets the mucosal immune system directly—where it can activate regulatory T cells and tamp down inflammation without triggering a full-body immune response. This approach could represent a leap forward in immunomodulation. And it's already showing signs of real-world benefit. What's Happening in Alzheimer's: Inflammation Down, Engagement Up
In July 2025, (TLSA) dropped major news: in a patient with moderate Alzheimer's disease, nasal foralumab not only showed safety and tolerability—it was linked with measurable immune changes and visible reductions in brain inflammation. 
PET scans demonstrated decreased microglial activation—an essential marker for neuroinflammation. Even more intriguing? An increase in phagocytosis markers in classical monocytes—suggesting foralumab could assist the body's own immune cells in clearing amyloid plaques, a hallmark of Alzheimer's pathology. The patient's condition didn't just improve biologically. According to the family, behavior and engagement improved, too. And the patient has since opted to continue therapy. A Strategic Expansion into Multiple Sclerosis (MS)
Alzheimer's isn't the only space where foralumab is being deployed. (TLSA) is currently advancing a Phase 2 randomized, double-blind, placebo-controlled trial in non-active Secondary Progressive Multiple Sclerosis (na-SPMS)—an area where current therapies fall short. The trial is underway across top-tier research centers, including Brigham and Women's, Yale, Johns Hopkins, and most recently, Weill Cornell. In a prior 10-patient observational study, the results were eye-catching: - Disease stability or improvement in all patients over 6 months
- Imaging showed reduced microglial inflammation
- Fatigue reduction in 6 of 10 patients
- No new lesions on MRI
Most importantly, no serious adverse effects were reported. Why This Could Matter
Right now, patients with non-active SPMS have few viable options. Alzheimer's therapies continue to fall short, particularly in moderate-stage disease. And ALS continues to challenge researchers worldwide. (TLSA)'s foralumab—delivered intranasally—might be the outlier that breaks the cycle. It's already showing immune modulation, CNS penetration, safety, and early efficacy signals across multiple conditions. More than that, it's doing so with a patented delivery method, a clean safety profile, and the potential for broad pipeline expansion into other neuroinflammatory diseases. One More Thing: Insider Confidence
In May 2025, Tiziana's Executive Chairman Gabriele Cerrone acquired 15K more shares on the open market, bringing his total stake to over 43Mn shares, or more than 37% of the company's issued capital. That kind of long-term skin in the game isn't something you see every day. It's not just "the science." It's the alignment—on the chart, in the clinic, and inside the boardroom. From insider conviction to technical strength and expanding third-party validation, there could be a pattern forming here. And if you're tracking where attention could shift next, this setup deserves to be front and center. 7 Reasons Why (TLSA) Is Topping Our Watchlist This Morning
—Wednesday, July 30, 2025…
1. Recent Momentum: (TLSA) went from $0.63 to $1.98 over the past 6 months—an approximate 214% move, reflecting sustained momentum on the chart. 2. Analyst Coverage: Last week, Lucid Capital Markets initiated coverage on (TLSA) with a target of $8—projecting over 300% upside from recent levels. 3. Technical Signals: (TLSA) is trending above its 5, 20, 50, 100, and 200-day moving averages, confirming strong short- and long-term alignment. 4. Insider Confidence Deepens: In May, (TLSA)'s Executive Chairman increased his position to over 43 mln shares—representing more than 37% of issued capital. 5. Real Impact in Alzheimer's: PET imaging from (TLSA)'s intranasal foralumab program showed reduced brain inflammation and immune modulation in a treated patient. 6. Clinical Sites Keep Growing: (TLSA)'s Phase 2 trial in non-active SPMS is now live at top-tier centers including Weill Cornell, Yale, and Johns Hopkins. 7. Immune-Targeting Innovation: (TLSA)'s nasal delivery avoids systemic immune disruption and may offer a safer path to CNS immune regulation across multiple diseases. The potential for momentum could pick up. Names like this don't stay quiet for long—especially when the setup checks this many boxes. The timing here couldn't be more critical. Pull Up (TLSA) This Morning—While It's Still Early…
Tiziana Life Sciences (Nasdaq: TLSA) isn't another biotech trying to push recycled therapies into crowded indications. It's doing something genuinely different—and based on emerging clinical data and third-party validation, it might be on the verge of making a mark in some of the most challenging conditions in neurology. With strong chart momentum, expanding analyst coverage, insider alignment, and emerging clinical signals in areas like Alzheimer's and SPMS, Tiziana Life Sciences (Nasdaq: TLSA) is beginning to separate itself from the noise. The combination of technical strength and early scientific traction makes this a setup worth watching closely. We have all eyes on (TLSA) this morning. Take a look at this while it's still early. Keep an eye out for my next update—it could be here within the next 60-90 minutes. Sincerely,
Jeff Ackerman
Managing Editor
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