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| & RYSE** | Good day, 360! | Here are some of our top movers today. Don't forget Jason's NEW $2000 Small Account Journey starts today. Get in for a low as $197 🔥. Be the best prepared trader on the Street! | | FOCUS LIST🔎 | PPBT - Up over 70% in the pre-market after reporting positive final results from randomized Phase 2 study of CM24 in second line pancreatic cancer | SNTI - Up over 80% in pre after announcing positive initial clinical data in Phase 1 clinical trial of SENTI-202, a logic gated, selective CD33/FLT3- targeting CAR-NK Cell therapy for the treatment of relapsed/refractory Hematologic Malignancies Including AML | VMAR- Up over 14% in pre after announcing production partnership with Massimo Marine Announce for first commercial electric pontoon platform | | In partnership with | |
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| | HOTLIST🔥 | PPBT - Up over 70% in the pre-market after reporting positive final results from randomized Phase 2 study of CM24 in second line pancreatic cancer | Purple Biotech Ltd. (PPBT) is a clinical-stage company that focuses on developing therapies to overcome tumor immune evasion and drug resistance for cancer patients in the United States. | In the pre-market this morning, the company reported positive final results from the randomized Phase 2 study of its lead oncology drug, CM24, a humanized monoclonal antibody that blocks CEACAM1, in patients with pancreatic ductal adenocarcinoma (PDAC). | Highlights include: | Final data demonstrate CM24 in combination with nivolumab and Nal-IRI/5FU/LV chemotherapy clear and consistent improvement across all efficacy endpoints A biomarker enriched patient population analysis based on pretreatment ranges of serum CEACAM1 demonstrated significant improvement in the treatment arm over the control of 79% reduction in risk of death (HR 0.21, P = 0.04) with median OS improvement of 5.1 months and over 90% reduction in risk of progression or death (HR < 0.1, P = 0.003) with median PFS improvement of 2.9 months and improvement in the treatment arm over the control in ORR of 50% vs. 0%.
Phase 2b clinical study is planned in multiple selected indications, potentially targeting patients based on biomarkers
| Shares of PPBT traded up over 70% in the pre-market in reaction to the news. | | The $4.90 area acted as support in the pre-market and will be an important level to watch. | Above it, targets to the upside are $5.60, $6, $6.50 and then the pre-market high at $6.70. Beyond that $7.80, $8.30 and $10 come into play. | Below $4.90, targets to the downside are $4.65, $4, $3.81, $3.65 and then a gap fill at $3.36. | | SNTI - Up over 80% in pre after announcing positive initial clinical data in Phase 1 clinical trial of SENTI-202, a logic gated, selective CD33/FLT3- targeting CAR-NK Cell therapy for the treatment of relapsed/refractory Hematologic Malignancies Including AML | Senti Biosciences Inc. (SNTI) operates as a preclinical biotechnology company that develops next-generation cell and gene therapies engineered with its gene circuit platform technologies for various diseases. | In the pre-market this morning, the company announced reported positive initial clinical data from a Phase 1 clinical trial of SENTI-202, a potential first-in-class Logic Gated off-the-shelf chimeric antigen receptor natural killer ("CAR-NK") investigational cell therapy, for the treatment of relapsed/refractory ("R/R") hematologic malignancies including acute myeloid leukemia ("AML"). | In addition, SNTI announced and oversubscribed $37.6 Million Private Placement Equity Financing. | Highlights include: | – 2 of 3 patients achieved MRD negative CR in the first dose level evaluated in the trial with a generally well-tolerated preliminary safety profile | – Dose escalation is continuing with additional response and durability data expected in 2025 | Shares of SNTI traded up over 80% in the pre-market in reaction to the news. | | The first target for bulls is the pre-market high at $6.34. Above it, targets to the upside are $7, $7.43 and $8.48. | Below $6.34, targets to the downside are $5.50, $4.50, $4, $3.70, $3, $2.50 and then a gap fill at $2.16. | | sponsored by RYSE** | Amazon Bets Big on Smart Homes, You Can Too | VCs know how difficult it is to spot promising early investment opportunities. Even the Sharks from Shark Tank declined the offer to buy 10% of Ring for $700,000 - a decision they would regret when Amazon acquired Ring, turning the $700,000 into $10M! | RYSE is the smart-home brand poised to follow a similar trajectory. The founder pitched on Canada's version of Shark Tank, Dragons' Den and received two offers - it seems the Dragons' learned from the Sharks' mistakes. Don't make the same mistake the sharks did. | Invest now. |
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| | VMAR- Up over 14% in pre after announcing production partnership with Massimo Marine Announce for first commercial electric pontoon platform | Vision Marine Technologies Inc. (VMAR) designs, develops, manufactures, sells, and rents electric boats in Canada, the United States, and internationally. | Over the weekend, the company announced a milestone partnership with Massimo Marine, the marine division of Massimo Group (MAMO). This collaboration will produce a fully integrated 30-foot electric pontoon platform designed for commercial and recreational markets. As part of Vision Marine's strategic shift to offer complete electric boats directly to consumers, this partnership represents a key step in rapidly delivering high-quality electric marine products to market. | In 2023, pontoon boat sales reached 115,000 units, a 5% increase over 2022 (https://pontoonboatguy.com/). This robust market growth reflects the demand for versatile and family-friendly watercraft. | Shares of VMAR traded up over 14% in the pre-market in reaction to the news. | | The $2.40 area acted as support in the pre-market and will be an important level to watch. Above it, targets to the upside are $2.80, $3, $3.20, $3.40, $3.60 and then the pre-market high at $3.90. | Below $2.40, targets to the downside are $2.35 and then a gap to fill at $2.20. | | MARKET NEWS 📰 | | | Questions or concerns about our products? Email Support@360wallstreet.io © Copyright 2022, RagingBull | | DISCLAIMER: To more fully understand any Ragingbull.com, LLC ("RagingBull") subscription, website, application or other service ("Services"), please review our full disclaimer located at https://ragingbull.com/disclaimer | FOR EDUCATIONAL AND INFORMATION PURPOSES ONLY; NOT INVESTMENT ADVICE. 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