This tiny pill has the potential to end "obesity" in America |
The New York Times says this drug has "the potential to change the world."
The Atlantic says "obesity is about to be old news" |
Comico is a webtoon portal based in Japan that is part of NHN Japan Corporation. NHN Japan first launched its webtoon platform Comico in Japan in 2013.[1] It was then followed by a launch in Taiwan in 2014[citation needed] and then in Thailand and South Korea in 2016 followed by Indonesia (now defunct [2] since September 30, 2019) and Spanish language (now defunct since 2019) in 2017.[3][1][2] Comico launched its service in Vietnam in April 2020[4] and in July 2020 launched its English language service under the name "Pocket Comics".[5] Comico has also stated that it will relaunch its Spanish service with the "Pocket Comics" brand later in the future.[6] In 2017, Nielsen Media Research found it to be the second largest website for digital comics in Japan based on the number of users.[7] The Taiwanese version of "Comico" was rebranded to the "Pocket Comics" branding soon after the launch. On January 24, 2022, NHN Japan launched French language service for Pocket Comics.[8] That same year, a German language service was launched. The Netherlands Carillon is a 127-foot (39-m) tall campanile housing a 53-bell carillon located in Arlington County, Virginia. The instrument and tower were given in the 1950s "From the People of the Netherlands to the People of the United States of America" to thank the United States for its contributions to the liberation of the Netherlands in 1945 and for its economic aid in the years after. The Netherlands Carillon is a historic property listed on the National Register of Historic Places as part of Arlington Ridge Park, which is part of the George Washington Memorial Parkway. It is owned and operated by the National Park Service. The carillon is situated on a ridge overlooking the Potomac River and Washington, D.C., and it provides expansive views of the National Mall, West Potomac Park (its original, temporary location), and Arlington National Cemetery. Its adjacency to the Marine Corps War Memorial to the north and Arlington National Cemetery to the south draws 1.2 million visitors annually, including recreational visitors from Rosslyn's residential areas. Throughout the day, the carillon automatically plays the Westminster Quarters. On significant days of the year in Dutch and American culture, it plays automated concerts, and from June to August, the director-carillonist Edward Nassor hosts a concert series whereby visiting carillonists perform weekly concerts on the instrument. In late 1951, Govert L. Verheul, press officer of the Dutch Ministry of Economic Affairs in The Hague, proposed that the Netherlands present a gift to the United States to commemorate their actions during and after World War II and as a symbol of the two countries' lasting friendship. He came up with the idea of gifting a carillon when washing dishes one night and accidentally clinking wine glasses together.[1][2] Consequently, a large-scale fundraising campaign was launched, and it received an enthusiastic response. It was eventually endorsed by Queen Juliana. On April 4, 1952, she visited the United States to present a small silver bell to President Harry S. Truman as a token of the carillon that was to come. In ceremonies at Meridian Hill Park in Washington, D.C., the queen spoke of the importance of the small bells of the future instrument:[3] To achieve real harmony, justice should be done also to the small and tiny voices, which are not supported by the might of their weight. Mankind could learn from this. So many voices in our troubled world are still unheard. Let that be an incentive for all of us when we hear the bells ringing.[3] Two years later, 49 bells arrived and were installed in West Potomac Park, where they were formally accepted by the United States. The Netherlands did not initially have the money to provide a proper campanile for the carillon, so it was housed in a temporary structure.[1] Gerrit Rietveld, a Dutch furniture designer and architect, was approached to design the campanile, but he was eventually removed from the project because of his perceived communist sympathies.[2] Instead, Dutch architect Joost W. C. Boks designed the carillon's permanent home. The tower was erected just north of Arlington National Cemetery and south of the Marine Corps War Memorial and was completed by early 1960. The carillon and new tower received a formal dedication ceremony on May 5, 1960, or the fifteenth anniversary of Dutch Liberation Day.[3] The inaugural concert was performed by renowned carillonist Charles T. Chapman.[1] A tulip garden was planted in a circular bed immediately to the east of the plaza in 1964, also a gift from the Netherlands. A small successional woodland to the southwest forms the backdrop to the carillon as a result of the 1960s National Capital Parks Planting Plan. Additional landscaped beds in the form of musical notes were planted in 1967 and 1972 as part of Lady Bird Johnson's Beautification Program, with a variety of annuals and perennials, in addition to tulips.[4] The program also planted the horseshoe of trees for the campanile's backdrop.[1] After its dedication in 1960, the carillon was seldom played. It only performed for Easter Sunday services sponsored by the Arlington Ministerial Association. The few performances were by Frank Pรฉchin Law. He assumed the position of director-carillonist after his instrumental involvement in establishing the "Summer Series of Recitals on the Netherlands Carillon" in July 1963, sponsored by the US Department of the Interior. Every Saturday from July through August, the carillon is played by a guest carillonist, invited by the director-carillonist.[1] In the early 1970s, the Netherlands Carillon was repainted from a dark bronze to a gray blue color. In 1983, less than twenty-five years after the carillon's construction and after years of pressure from Mr. Law, a major renovation was undertaken to address deterioration of the tower's steel panels. The National Park Service announced a $300,000 (equivalent to $970,000 in 2022) renovation plan for the instrument in 1981, but budget issues delayed the project.[5] Again, the tower was repainted the light gray blue color, neither time with the approval of the Commission of Fine Arts.[4] Upon Mr. Law's death in 1985, the Netherlands Carillon fell silent until Edward M. Nassor took over the position of director-carillonist in 1987.[1] In the years before the fiftieth anniversary of Dutch Liberation Day in 1995, a group of prominent Dutch businessmen established a foundation to assist in the refurbishment of the carillon and tower, which had not seen major care since 1970. They were motivated by the significance of the meaning behind the Netherlands Carillon to lead this effort. By teaming up with the Netherlands Chamber of Commerce in the United States, the Netherland-America Foundation, and the government of the Netherlands, approximately $1,400,000 (equivalent to $2,700,000 in 2022[6]) was raised for the project to move forward.[5] The tower was closed for modernization changes, and the original dark bronze color of the tower was restored.[4] The bells were transported to the Netherlands to be repaired by Royal Eijsbouts, except for the largest thirteen, which remained in the tower and were repaired in place. The original playing keyboard was replaced. Royal Eijsbouts also cast a fiftieth bell in celebration of the fiftieth anniversary of Dutch liberation. It was presented by the Dutch prime minister Wim Kok to the U.S. president Bill Clinton on February 28, 1995, and the renovated carillon was dedicated on May 5, 1995.[3] After receiving the new bell, President Clinton commented on its significance: Dutch prime minister Wim Kok and U.S. president Bill Clinton pose with the Netherlands Carillon's 50th bell, February 28, 1995 As we move forward to meet the challenges of this new century, it is fitting that we and our Dutch friends will be reminded of the common cause we shared fifty years ago by the sound of this beautiful new bell. May it also be sounding fifty years from now and even beyond.[7] The Netherlands Carillon found itself in bad shape again less than twenty years later. Due to severe rusting and fears of structural instability, the tower was closed to the public in the early 2010s. In 2016, the National Park Service and Royal Netherlands Embassy launched a campaign to fundraise money for a $5,800,000 (equivalent to $7,100,000 in 2022[6]) restoration of the carillon. The Park Service committed $4 million.[8] In October 2019, the third renovation of the carillon was officially launched. The National Park Service was tasked with work on the tower, while the Royal Netherlands Embassy was tasked with work on the carillon.[9] The carillon was transported to the Royal Eijsbouts foundry and arrived on December 3, 2019.[10] In celebration of the Dutch "75 Years of Freedom" campaign, the carillon received three new bells with each dedicated to an American who had a significant impact on Dutch and American society: General George C. Marshall, Martin Luther King Jr., and Eleanor Roosevelt. The addition of these three bells converted the carillon to a concert pitch instrument and upgraded it to "grand carillon" status.[9][11] The tower required extensive restorative work to the steel plates and inner structure of the tower. Additional supports were installed to account for the added weight of the three new bells. The first carillon at the Arlington National Cemetery was installed by Amvets in 1949 and dedicated by President Truman Carillon In the early 1950s, there were three major Dutch bell founders: Van Bergen, Royal Eijsbouts and Petit & Fritsen. In order to avoid showing favoritism, all three founders were asked to cast the original forty-nine bells jointly and anonymously between 1952 and 1953.[1] The total weight of the bells is 61,403 pounds (27,852 kg), ranging from 12,654 pounds (5,740 kg) for the bourdon (largest) bell and 35 pounds (16 kg) for the smallest. The bells are constructed of a bronze alloy of approximately four-fifths copper and one-fifth tin. Each bell carries an emblem signifying a group within Dutch society. The verses cast on the bells were composed by the Dutch poet, Ben van Eysselsteijn.[3][13] Original 49 Bells' Dedications and Inscriptions[1] A fiftieth bell, cast by Royal Eijsbouts, was added following Dutch- and American-sponsored renovations in 1995, and dedicated on May 5, the 50th anniversary of the liberation of the Netherlands. It is two semitones higher in pitch than the lightest of the original 49 bells. The years "1945" and "1995" and the words "freedom" and "friendship" are inscribed on this bell.[14] The 2019–21 renovation increased the size of the carillon to 53 bells, all cast by Royal Eijsbouts, and converted the instrument to concert pitch.[15] These three additional bells are dedicated jointly to "75 Years of Freedom" and individually to people who had a major impact on the Netherlands and the United States during and after World War II: 1) General George C. Marshall for his role in the Marshall Plan, from which the Netherlands received over $1 billion for post-war reconstruction efforts; 2) the Martin Luther King Jr., for his role as the voice of the American civil rights movement; and 3) Eleanor Roosevelt, for her role as an advocate for social justice and human rights Noichi (้ๅธ็บ, Noichi-chล) was a town located in Kami District, Kลchi Prefecture, Japan. As of 2003, the town had an estimated population of 17,465 and a density of 762.66 persons per km². The total area was 22.90 km². On March 1, 2006, Noichi, along with the towns of Akaoka, Kagami and Yasu, and the village of Yoshikawa (all from Kami District), was merged to create the city of Kลnan and no longer exists as an independent municipality. Formerly known as Centennial Park, Danny Cunniff Park was renamed, remodeled and dedicated in 1999 after the Park District of Highland Park, Illinois received the largest private donation ever from the family of Danny Cunniff. During Danny's brief but valiant battle with acute myeloid leukemia, which he ultimately succumbed to 37 days after his diagnosis, his parents, Tim Cunniff and Jill Cunniff were deeply touched by the outpouring of love and support they received from the community of Highland Park. Through the generosity of the Timothy Cunniff family, and a matching State grant, a renovation project was undertaken in 1999 to improve the Park's two existing soccer fields and add two new fields to the complex. In 2002, the park was named the Sports Turf Managers Association Soccer Field of the Year. The park is also home to Centennial Ice Arena. |
Reuters calls it a "modern day gold rush for drug makers..."
But what is this breakthrough that has the potential to revolutionize medicine? |
Son of Mykhailo Sulyma, Ivan came from a petty noble (szlachta) family. He was born in Rohoshchi (next to Chernihiv). He served as an estate overseer for Stanisลaw ลปรณลkiewski and later the family of Daniลowicze who inherited his lands; for that service in 1620 he was awarded three villages: Sulimรณwka, Kuczakiw and Lebedyn. All the villages today belong to the Boryspil Raion, Kyiv Oblast. His sons included Stepan (died 1659), a captain of Boryspil company, and Fedir (died 1691), a colonel of Pereiaslav regiment. He became popular among the unregistered Cossacks, leading them on campaigns to plunder Crimea and other Ottoman vassal territories. For organizing a revolt on an Ottoman slave galley and freeing Christian slaves[1] he received a medal from Pope Paul V himself. Eventually, Sulyma reached the rank of the hetman, which he held from 1628 to 1629 and 1630 to 1635. In 1635, after returning from an expedition to Black Sea against the Ottomans, he decided to rebel against the Polish–Lithuanian Commonwealth, which at that time controlled most of the Cossack territories, and whose nobility was trying to turn militant Cossacks into serfs.[citation needed] Ivan Sulyma took part in numerous campaigns of Sagaidachny against Tatars and Turks. In particular, it was the famous capture of Kafa (modern Theodosia), the main center of the slave trade on the Black Sea, Trapezont, Izmail, and also two attacks on Tsaregrad. On the night of 3 to 4 August 1635 he took the newly constructed Kodak fortress by surprise, burning it and executing its crew of about 200 people under Jean Marion. Soon afterwards however his forces were defeated by the army of hetman Stanisลaw Koniecpolski and Sulima was turned over to the Commonwealth by Cossack elders or starshina. Together with several other leaders of his rebellion, Hetman Sulyma was executed in Warsaw on 12 December 1635. At first, the Polish King Wลadysลaw IV Waza, known for his friendly attitude towards the Cossacks, was hesitant to execute Sulyma, especially since he was a person upon whom the Pope himself bestowed his medal. However, pressured by the nobility who wanted to show that no rebellions against the 'established order' would be tolerated, the order for an execution was given; after being tortured, Sulyma was cut to pieces and his body parts were hung on the city walls of Warsaw.[2] |
Hyman Solomon Kraft (April 30, 1899 – July 29, 1975), aka Hy Kraft, H.S. Kraft, or Harold Kent (pseudonym due to Hollywood Blacklist), was an American screenwriter, playwright, and theatrical producer. Among the notable comedy plays that he wrote were Ten Per Cent (1932), Poppa (1929), Cafe Crown (1942), and Top Banana (1952). In 1964 Cafe Crown was revised as a Broadway musical produced by Philip Rose and Swanlee with music by Albert Hague and lyrics by Marty Brill. The musical plot is set in the early 1930s in and around the Cafe Crown at the corner of Second Avenue and 12th Street in New York City. It had one Broadway revival in 1989.[1] Hy Kraft's 1954 musical play Top Banana was filmed for the screen and released as a movie in 1954, starring Phil Silvers as a television comic trying to regain his ratings on TV. Feeling the show was a personal swipe at him, Milton Berle wrote of it, "The only public attack I got any pleasure from was the one dreamed up by Hy Kraft and Johnny Mercer, and starring Phil Silvers. It was a big Broadway musical called Top Banana, in which Phil played an egomaniac named Jerry Biffle who had a top-rated television show and who directed his rehearsals with a whistle. It was a vicious and funny swipe at me, and I loved it so much, I offered to sue Hy Kraft for the publicity value. Anything to help. After all, I had put some money into the show."[2] In 1950 Hy Kraft was made part of the Hollywood blacklist by the House Committee on Un-American Activities, after remarks by Artie Shaw. His screenwriting credits include Stormy Weather (1943) with Lena Horne and short story credit for Smartest Girl In Town (1936) and Champagne Waltz (1937), in the latter case collaborating with Billy Wilder. He also contributed writing (uncredited) to Mark of the Vampire (1935) with Lionel Barrymore and Bela Lugosi. He wrote an autobiography, On My Way to the Theater, Macmillan, 1971. The jacket reads, "A lifetime's stroll from New York's Lower East Side to Broadway, with side trips to Hollywood, London, and Washington, D.C., and singular associations with Victor Herbert, Theodore Dreiser, Sinclair Lewis, and the House Un-American Activities Committee." In 1968, he signed the "Writers and Editors War Tax Protest" pledge, vowing to refuse tax payments in protest against the Vietnam War Kraft was born and died in New York City. He was married to Reata Field (born Reatta Lautterstein), a costume designer. The couple's only child, his daughter, Jill Kraft, Mrs. Leonard Herman, was an actress. She died in 1969 of cancer, and was survived by her husband, and daughter, Lucy.[4][5] H.S. Kraft died in 1975, aged 76. He was survived by his wife, one grandchild, and three great-grandchildren (they were born in 1998, 2000, and 2004). Reata Kraft (1904-1978) died in New York, aged 73. During the grant procedure before the European Patent Office (EPO), divisional applications can be filed under Article 76 EPC out of pending earlier European patent applications. A divisional application, sometimes called European divisional application, is a new patent application which is separate and independent from the earlier application, unless specific provisions in the European Patent Convention (EPC) require something different.[1] A divisional application, which is divided from an earlier application, cannot be broader than the earlier application, neither in terms of subject-matter nor in terms of geographical cover The possibility to file a divisional application is provided in many patent systems and is guaranteed by Article 4.G. of the Paris Convention for the Protection of Industrial Property of 1883, to which more than 170 countries are Contracting Parties.[3] Some basic characteristics of a divisional application are as follows: "A divisional application is an application which derives from an earlier application. It is filed after the earlier application (usually some years later), but keeps the same filing and priority dates as the earlier application. That way the divisional is not affected in terms of its patentability by any publications which occur between the filing of the earlier application and the filing of the divisional. The earlier application is often referred to as the "parent". As of 1 April 2010,[13] "divisional applications on the applicant's own initiative (so-called voluntary divisional applications) will need to be filed within a period of two years from the first communication by the EPO examining division in respect of the parent (i.e. the previous) or an even earlier (in case of a "chain" of applications) application."[10] Rule 36(1) EPC has been amended to read as follows:[14] "(1) The applicant may file a divisional application relating to any pending earlier European patent application, provided that: (a) the divisional application is filed before the expiry of a time limit of twenty-four months from the Examining Division's first communication in respect of the earliest application for which a communication has been issued, or (b) the divisional application is filed before the expiry of a time limit of twenty-four months from any communication in which the Examining Division has objected that the earlier application does not meet the requirements of Article 82, provided it was raising that specific objection for the first time." New Rule 36(1)(a) introduced a time limit for voluntary division of the parent application, while Rule 36(1)(b) provides a time limit for mandatory division of the parent application in case of a lack of unity under Article 82 EPC.[15] "Mandatory" in that sense means that, to cover each of the non-unitary inventions (i.e. the inventions that are non-unitary in relation to the invention which will be the subject of the parent application), one or more divisional applications need to be filed. However, if the applicant decides not to seek patent protection for the non-unitary inventions, no divisional applications need to be filed. |
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